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GS52
GST T2-2, Recombinant Human
Synonym(e):
glutathione S-transferase theta 2
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 μg | Warenkorb auf Verfügbarkeit prüfen | € 389,00 |
Über diesen Artikel
NACRES:
NA.26
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
25 kDa
Technischer Dienst
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Unterstützung erhaltenbiological source
human
Quality Level
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
frozen liquid
specific activity
12.6 units/mg protein
mol wt
25 kDa
concentration
1.91 mg/mL
storage temp.
−70°C
Gene Information
human ... GSTT2(2953)
General description
Glutathione S-transferase theta 2 (GSTT2) is an enzyme that in humans is encoded by the GSTT2 gene. GSTT2 is mapped to human chromosome 22q11.2.[1]
as assayed by the spectrophotometric determination of NADPH oxidation coupled to the glutathione peroxidase activity of GST T2-2 on cumene hydroperoxide (1.5 mM) in the presence of reduced glutathione (1 mM) in 100 mM NaPO4 (pH 7.0) at room temperature.
Biochem/physiol Actions
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, κ, μ, ω, π, σ, θ and ζ. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
The θ class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations.
Preparation Note
The enzyme should be used by the end-user customer within 1 year of receipt.
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Dieser Artikel | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| biological source human | biological source human | biological source human | biological source human |
| assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay 95% (SDS-PAGE) | assay >95% (SDS-PAGE) |
| concentration 1.91 mg/mL | concentration 2.55 mg/mL | concentration 1.95 mg/mL | concentration 2.0 mg/mL |
| mol wt 25 kDa | mol wt 26 kDa | mol wt 25 kDa | mol wt 23 kDa |
| form frozen liquid | form frozen liquid | form frozen liquid | form frozen liquid |
Lagerklasse
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Verwandter Inhalt
Glutathione S-transferases: an overview in cancer research.
Di Pietro G, et al.
Expert Opinion on Drug Metabolism & Toxicology, 6(2), 153-170 (2010)
Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.
Tan K L, et al.
Genomics, 25(2), 381-387 (1995)
Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases.
Allocati N, et al.
Oncogenesis, 7(1), 8-8 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GS52-100UG | 04061833655139 |