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GS05
GST S1-1, Recombinant Human
Synonym(e):
GSTS, GSTS1, PGD2, PGDS, hematopoietic prostaglandin D synthase
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 μg | Warenkorb auf Verfügbarkeit prüfen | € 389,00 |
Über diesen Artikel
NACRES:
NA.26
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
23 kDa
Technischer Dienst
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Unterstützung erhaltenbiological source
human
Quality Level
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
frozen liquid
specific activity
24.07
mol wt
23 kDa
concentration
0.9 mg/mL
storage temp.
−70°C
Gene Information
human ... HPGDS(27306)
General description
using spectrophotometric determination of 1-fluoro-2,4-dinitrobenzene (FDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Biochem/physiol Actions
Glutathione S-transferase sigma 1, also know as hematopoietic prostaglandin D synthase (HPGDS) is an enzyme that in humans is encoded by the HPGDS gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.
Preparation Note
The enzyme should be used by the end-user customer within 1 year of receipt.
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Dieser Artikel | |||
|---|---|---|---|
| assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| biological source human | biological source human | biological source human | biological source human |
| concentration 0.9 mg/mL | concentration 1.98 mg/mL | concentration 3.17 mg/mL | concentration 1.0 mg/mL |
| form frozen liquid | form frozen liquid | form frozen liquid | form frozen liquid |
| mol wt 23 kDa | mol wt 26 kDa | mol wt 26 kDa | mol wt 25 kDa |
Lagerklasse
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Verwandter Inhalt
Marcus Kjellander et al.
Analytical biochemistry, 446, 59-63 (2013-10-26)
The previously uncharacterized Drosophila melanogaster Epsilon-class glutathione transferases E6 and E7 were immobilized on nanoporous alumina. The nanoporous anodized alumina membranes were derivatized with 3-aminopropyl-triethoxysilane, and the amino groups were activated with carbonyldiimidazole to allow coupling of the enzymes via
Morten Hohwy et al.
Journal of medicinal chemistry, 51(7), 2178-2186 (2008-03-18)
We describe the discovery of novel inhibitors of prostaglandin D2 synthase (PGDS) through fragment-based lead generation and structure-based drug design. A library of 2500 low-molecular-weight compounds was screened using 2D nuclear magnetic resonance (NMR), leading to the identification of 24
Brigette L Tippin et al.
Prostaglandins & other lipid mediators, 97(1-2), 22-28 (2011-08-09)
Intestinal tumors in Apc(Min/+) mice are suppressed by over-production of HPGDS, which is a glutathione transferase that forms prostaglandin D(2) (PGD(2)). We characterized naturally occurring HPGDS isoenzymes, to see if HPGDS variation is associated with human colorectal cancer risk. We
Global Trade Item Number
| SKU | GTIN |
|---|---|
| GS05-100UG | 04061833654835 |