G1639

D-(+)-Galactosamin -hydrochlorid

BioReagent, suitable for cell culture

• Synonym(e): 2-Amino-2-deoxy-D-galactopyranose -hydrochlorid, D-Chondrosamin -hydrochlorid
• Empirische Formel (Hill-System): C₆H₁₃NO₅ · HCl
• CAS-Nummer: 1772-03-8
• Molekulargewicht: 215.63
• PubChem Substance ID: 24895072
• UNSPSC Code: 12352209
• MDL number: MFCD00135830
• NACRES: NA.75
• EC Number: 217-198-1
• Beilstein/REAXYS Number: 3697825

Eigenschaften

• biological source: fish cartilage (shark)
• Quality Level: 200
• product line: BioReagent
• assay: ≥99%
• technique(s): cell culture | mammalian: suitable
• impurities: Glucosamine, essentially free
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
• InChI: 1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
• InChI key: CBOJBBMQJBVCMW-NQZVPSPJSA-N

Beschreibung

Application

D-(+)-Galactosamine hydrochloride has been used to:

• induce livery injury
• inflammatory liver injury
• acute liver failure (ALF) in mice

Biochem/physiol Actions

Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure. It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)