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F5307

5−Fluoro−2′−deoxycytidine

≥98% (HPLC), powder

Synonym(e):

2′-deoxy-5-fluoro-Cytidine, FCDR, FdCyd

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F5307-5MG

€ 82,62

F5307-25MG

€ 321,30

€ 82,62

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Über diesen Artikel

Empirische Formel (Hill-System):
C9H12FN3O4
CAS-Nummer:
10356-76-0
Molekulargewicht:
245.21
NACRES:
NA.77
PubChem Substance ID:
329799711
UNSPSC Code:
12352200
MDL number:
MFCD00077348
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

NC1=NC(=O)N(C=C1F)[C@H]2C[C@H](O)[C@@H](CO)O2

InChI

1S/C9H12FN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h2,5-7,14-15H,1,3H2,(H2,11,12,16)/t5-,6+,7+/m0/s1

InChI key

IDYKCXHJJGMAEV-RRKCRQDMSA-N

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1 of 4

Dieser Artikel
D6571SML0653G6423
5−Fluoro−2′−deoxycytidine ≥98% (HPLC), powder

Sigma-Aldrich

F5307

5−Fluoro−2′−deoxycytidine

3′,4′-Dimethoxyflavone

Sigma-Aldrich

D6571

3′,4′-Dimethoxyflavone

Capecitabine ≥98% (HPLC)

Sigma-Aldrich

SML0653

Capecitabine

Gemcitabine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

G6423

Gemcitabine hydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: >20 mg/mL

solubility

DMSO: ≥20 mg/mL

solubility

H2O: 10 mg/mL, clear (warmed)

solubility

H2O: ≥10 mg/mL

color

white to off-white

color

white to off-white

color

white to beige

color

-

Biochem/physiol Actions

5-Fluoro-2′-deoxycytidine is a mechanism based DNMT (DNA cytosine-5 methyltransferase) inhibitor, that forms a covalent link with the cysteine residue in the active site of DNMT.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
059K4720V
059K47201
059K4720

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

D A Boothman et al.
Cancer research, 47(9), 2344-2353 (1987-05-01)
Treatment of C57BL X DBA/2 F (hereafter called BD2F) mice bearing ascitic mammary adenocarcinoma-755 (ADC-755) with [3H]-5-fluoro-2'-deoxycytidine ([3H]FdCyd) plus tetrahydrouridine (H4Urd) resulted in antimetabolite pool sizes indicative of a tumor-selective, dual pathway metabolism of FdCyd via both cytidine deaminase and
Theodore C Jessop et al.
Bioorganic & medicinal chemistry letters, 19(23), 6784-6787 (2009-10-20)
A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford a highly potent, selective and orally bioavailable inhibitor, compound 10.
J A Yoder et al.
Journal of molecular biology, 270(3), 385-395 (1997-07-18)
The mechanisms that establish and maintain methylation patterns in the mammalian genome are very poorly understood, even though perturbations of methylation patterns lead to a loss of genomic imprinting, ectopic X chromosome inactivation, and death of mammalian embryos. A family
M Iigo et al.
Cancer chemotherapy and pharmacology, 20(1), 1-4 (1987-01-01)
The plasma concentration of 5-fluorouracil (FUra) following the i.v. administration of FUra and guanosine 5'-monophosphate (GMP) or guanosine 5'-triphosphate (GTP) was markedly elevated. These values were more than 5-fold higher than those obtained with FUra alone over 60 min after
G Ia Sheflian et al.
Biokhimiia (Moscow, Russia), 58(11), 1806-1811 (1993-11-01)
Cleavage by restriction endonucleases MvaI kappa EcoRII of DNA duplexes, in which the internal deoxycytidine in one of the strands of the recognition site is substituted for 5-fluorodeoxycytidine, has been studied. It has been found that the modified strands of
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