EPS003

CUDC 101

A potent inhibitor of HDACs and receptor tyrosine kinases

• Synonym(e): 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide, Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy
• Empirische Formel (Hill-System): C₂₄H₂₆N₄O₄
• CAS-Nummer: 1012054-59-9
• Molekulargewicht: 434.49
• MDL number: MFCD15528940
• UNSPSC Code: 12352200
• NACRES: NA.41
• Assay: ≥98% (HPLC)

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• color: white
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: N(O)C(=O)CCCCCCOc1cc2c(ncnc2Nc3cc(ccc3)C#C)cc1OC
• InChI: 1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
• InChI key: PLIVFNIUGLLCEK-UHFFFAOYSA-N

Beschreibung

General description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable