E1127

β-Estradiol 17-(β-D-glucuronide) sodium salt

≥98% (HPLC), Estradiol metabolite, powder

• Synonym(e): 1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide
• Lineare Formel: C₂₄H₃₁O₈Na
• CAS-Nummer: 15087-02-2
• Molekulargewicht: 470.49
• UNSPSC Code: 51111800
• PubChem Substance ID: 24894388
• NACRES: NA.77
• MDL number: MFCD00056557
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: β-Estradiol 17-(β-D-glucuronide) sodium salt,
• sterility: non-sterile
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• solubility: 0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
• InChI: 1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;
• InChI key: GPLPNZUTAJWRLU-UHFFFAOYSA-N

Beschreibung

Application

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay. It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).

Biochem/physiol Actions

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H351
• pcodes: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges