E0159

Efonidipine hydrochloride monoethanolate

≥98% (HPLC)

• Empirische Formel (Hill-System): C₃₄H₃₈N₃O₇P · HCl · C₂H₅OH
• CAS-Nummer: 111011-76-8
• Molekulargewicht: 714.18
• MDL-Nummer: MFCD00875717
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798945
• NACRES: NA.25

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: pale yellow
• Löslichkeit: DMSO: >5 mg/mL; H₂O: insoluble
• Ersteller: Shionogi
• Lagertemp.: 2-8°C
• SMILES String: Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5
• InChI: 1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H
• InChIKey: IKBJGZQVVVXCEQ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Leistungsmerkmale und Vorteile

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)