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D5564
7,8-Dihydroxycumarin
≥97%, powder
Synonym(e):
Daphnetin, Daphnetol, Ruixiangsu
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 107,00 | |
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 413,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C9H6O4
CAS-Nummer:
Molekulargewicht:
178.14
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
207-632-8
MDL number:
Technischer Dienst
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Unterstützung erhaltenbiological source
synthetic (organic)
Quality Level
assay
≥97%
form
powder
solubility
ethanol: 5 mg/mL
storage temp.
room temp
SMILES string
Oc1ccc2C=CC(=O)Oc2c1O
InChI
1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChI key
ATEFPOUAMCWAQS-UHFFFAOYSA-N
Biochem/physiol Actions
7,8-Dihydroxycoumarinan is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma. It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥97% | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| solubility ethanol: 5 mg/mL | solubility DMSO: ≥5 mg/mL | solubility DMSO: >5 mg/mL | solubility DMSO: ≥5 mg/mL |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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E B Yang et al.
Biochemical and biophysical research communications, 260(3), 682-685 (1999-07-15)
Protein kinases play key roles in the control of cell proliferation, differentiation and metabolism. In this work, we studied the effect of coumarin and its derivatives, including daphnetin, esculin, 2-OH-coumarin, 4-OH-coumarin and 7-OH-coumarin, on the activity of protein kinases. It
7, 8-dihydroxycoumarin may promote sciatic nerve regeneration by suppressing NF-kappaB expression in mice
Du JS, et al.
Molecular Medicine Reports, 8(5), 1525-1530 (2013)
7, 8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of AktNF-kappaB signaling
Wang Y, et al.
Experimental and Therapeutic Medicine, 5(6), 1770-1774 (2013)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D5564-5MG | 04061832434018 |
| D5564-25MG | 04061832434001 |