SML0273

VAS2870

≥97% (HPLC), NOX4 inhibitor, powder

• Synonym(e): 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine, VAS 2870, VAS-2870
• Empirische Formel (Hill-System): C₁₈H₁₂N₆OS
• CAS-Nummer: 722456-31-7
• Molekulargewicht: 360.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825281
• NACRES: NA.77
• MDL number: MFCD03407188
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Produktname: VAS2870, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥5 mg/mL
• storage temp.: room temp
• SMILES string: C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23
• InChI: 1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
• InChI key: HZSOKHVVANONPV-UHFFFAOYSA-N

Beschreibung

Application

VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:

• to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly[1]
• to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice[2]
• to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes[3]

Biochem/physiol Actions

In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types.[4] It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.[5]

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable