D3630

Diphenhydramin -hydrochlorid

≥98% (HPLC), H1 histamine receptor antagonist, powder

• Synonym(e): 2-Diphenylmethoxy-N,N-dimethylethylamin -hydrochlorid, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₇H₂₁NO · HCl
• CAS-Nummer: 147-24-0
• Molekulargewicht: 291.82
• NACRES: NA.77
• PubChem Substance ID: 24277771
• UNSPSC Code: 12352116
• EC Number: 205-687-2
• MDL number: MFCD00012479
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Diphenhydramin -hydrochlorid, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• originator: Johnson & Johnson
• SMILES string: Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
• InChI: 1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
• InChI key: PCHPORCSPXIHLZ-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Beschreibung

Application

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation[1]
as an antihistamine in experimental studies

Biochem/physiol Actions

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves