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D1156

N,N-Dimethylglycin

Name: <I>N</I>,<I>N</I>-Dimethylglycin
Brand: SIGMA

≥99%, suitable for ligand binding assays

Synonym(e):

Dimethylamino-essigsäure

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Packungsgröße	SKU	Verfügbarkeit	Preis

Über diesen Artikel

Lineare Formel:

(CH₃)₂NCH₂COOH

CAS-Nummer:

1118-68-9

Molekulargewicht:

103.12

NACRES:

NA.26

PubChem Substance ID:

24893366

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

214-267-8

MDL number:

MFCD00004283

Beilstein/REAXYS Number:

1700261

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Unterstützung erhalten

Produktname

N,N-Dimethylglycin, ≥99%

Quality Level

200

assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

178-182 °C (lit.)

application(s)

peptide synthesis

SMILES string

CN(C)CC(O)=O

InChI

1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)

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Dieser Artikel	D6382	A1879	M2383
Sigma-Aldrich D1156 N,N-Dimethylglycine	Sigma-Aldrich D6382 N,N-Dimethylglycine hydrochloride	Sigma-Aldrich A1879 L-2-Aminobutyric acid	Sigma-Aldrich M2383 α-(Methylamino)isobutyric acid
form powder	form powder	form powder	form powder
technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable
assay ≥99%	assay ≥98%	assay ≥99% (titration)	assay ≥97% (titration)
mp 178-182 °C (lit.)	mp 189-194 °C (lit.)	mp -	mp >300 °C (lit.)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
color white to off-white	color white	color white	color white

Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Metabolic profiling detects biomarkers of protein degradation in COPD patients.

Baljit K Ubhi et al.

The European respiratory journal, 40(2), 345-355 (2011-12-21)

There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers

Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study.

S H Moolenaar et al.

Clinical chemistry, 45(4), 459-464 (1999-04-02)

A38-year-old man presented with a history of fish odor (since age 5) and unusual muscle fatigue with increased serum creatine kinase. Our aim was to identify the metabolic error in this new condition. We used 1H NMR spectroscopy to study

Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.

B A Binzak et al.

American journal of human genetics, 68(4), 839-847 (2001-03-07)

Dimethylglycine dehydrogenase (DMGDH) (E.C. number 1.5.99.2) is a mitochondrial matrix enzyme involved in the metabolism of choline, converting dimethylglycine to sarcosine. Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1). Both enzymes use flavin adenine dinucleotide and

Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients.

Ali A Moazzami et al.

The Journal of nutrition, 141(12), 2126-2132 (2011-10-21)

Prostate cancer (PC) is the most common cancer in the Western world and the second most important cancer causing male deaths, after lung cancer, in the United States and Britain. Lifestyle and dietary changes are recommended for men diagnosed with

Tolerance and safety evaluation of N,N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets.

Isabelle D Kalmar et al.

The British journal of nutrition, 107(11), 1635-1644 (2011-09-21)

N,N-Dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. The objective of the present trial was to evaluate tolerance, safety and bioaccumulation of dietary DMG in broilers when supplemented at 1 g

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Global Trade Item Number

SKU	GTIN
D1156-10MG	04061833558805
D1156-5G	04061833558812
D1156-10G	04061833558799
D1156-25G	04061832416137

Questions

1–2 of 2 Questions

Anonymous

8 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  8 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

a year ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  a year ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?

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