C8849

α-Chloralose−HBC complex

Name: α-Chloralose−HBC complex
Brand: SIGMA
Price: 286.45 EUR

≥92% α-anomer basis

Synonym(e):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose: 2-hydroxypropyl-β-cyclodextrin complex

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Über diesen Artikel

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥92% α-anomer basis

Form:

powder

Quality level:

100

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assay

≥92% α-anomer basis

form

powder

shelf life

4 weeks at 4 °C (for aqueous solutions)

solubility

H₂O: freely soluble

Quality Level

100

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Dieser Artikel	C0128	D5878	45373
Sigma-Aldrich C8849 α-Chloralose−HBC complex	Sigma-Aldrich C0128 α-Chloralose	Sigma-Aldrich D5878 Digitoxin	Supelco 45373 Chloralose
assay ≥92% α-anomer basis	assay -	assay ≥92% (HPLC)	assay -
form powder	form powder	form powder	form -
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
solubility H₂O: freely soluble	solubility ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow (or yellow-brown)	solubility chloroform: soluble	solubility -
shelf life 4 weeks at 4 °C (for aqueous solutions)	shelf life -	shelf life -	shelf life -

Application

α-Chloralose-HBC complex has been used for anesthetizing rats for various in vivo studies.[1][2][3]

Biochem/physiol Actions

α-Chloralose-HBC complex is a preferred anesthetic over isoflurane as it displays no intrusion retinal spreading depolarization (rSD) generation and propagation.[1]

Preparation Note

α-Chloralose content: 10% (w/w)

pictograms

GHS09

signalword

Warning

hcodes

H410

pcodes

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Lagerklasse

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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Measurement of Retinal Blood Flow Using Fluorescently Labeled Red Blood Cells.

Tess E Kornfield et al.

eNeuro, 2(2) (2015-06-18)

Blood flow is a useful indicator of the metabolic state of the retina. However, accurate measurement of retinal blood flow is difficult to achieve in practice. Most existing optical techniques used for measuring blood flow require complex assumptions and calculations.

Ischemia-induced spreading depolarization in the retina.

Anja I Srienc et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(9), 1579-1591 (2016-07-09)

Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina.

Kyle R Biesecker et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(36), 9435-9445 (2016-09-09)

The brain is critically dependent on the regulation of blood flow to nourish active neurons. One widely held hypothesis of blood flow regulation holds that active neurons stimulate Ca(2+) increases in glial cells, triggering glial release of vasodilating agents. This

A review of laboratory animal anesthesia with chloral hydrate and chloralose.

J Silverman et al.

Laboratory animal science, 43(3), 210-216 (1993-06-01)

Chloral hydrate (CH) and alpha-chloralose (CS) are often used to anesthetize laboratory animals although, to our knowledge, there have been no controlled studies of their anesthetic or analgesic effects. Induction of and recovery from anesthesia can be stressful, and anesthesia

Regulation of blood flow in the retinal trilaminar vascular network.

Tess E Kornfield et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11504-11513 (2014-08-22)

Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal blood vessels and increased blood flow. This response, named functional hyperemia, brings oxygen and nutrients to active neurons. However, it remains unclear which vessels mediate functional

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α-Chloralose−HBC complex