C7774
Human Collagen Type I
from human placenta, powder, suitable for cell culture
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)
About This Item
Empfohlene Produkte
product name
Kollagen aus menschlicher Placenta, Bornstein and Traub Type I (Sigma Type VIII), powder
Biologische Quelle
human placenta
Form
powder
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
HIV, hepatitis B and hepatitis C, none detected
Lagertemp.
2-8°C
Angaben zum Gen
bovine ... CSN2(281099) , CSN3(281728)
human ... COL4A3(1285) , COL4A4(1286) , COL4A6(1288)
Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich
Verwandte Kategorien
Anwendung
This product is intended to produce thin layer coatings on tissue culture plates to facilitate attachment of anchorage-dependent cells, recommended for use at 6-10 μg/cm2. It is NOT intended for production of 3-D gels. Type I collagen is often used in cell culture as an attachment substratum with myoblasts, spinal ganglia, hepatocytes, embryonic lung, heart explants, fibroblasts, endothelial cells, and islet cells have all been cultured successfully on films or gels of type I collagen. Collagen type I may also be used in research of Idiopathic pulmonary fibrosis (IPF), studies on the effect of ER stress IPF on lung fibroblasts. Collagen in acidic solution can produce three dimensional scaffolding with use in bioengineering and cell culture applications.
Biochem./physiol. Wirkung
Type I collagen is a component of skin, bone, tendon, and other fibrous connective tissues.
Komponenten
All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type I collagen differs from other collagens by its low lysine hydroxylation and low carbohydrate composition.
Angaben zur Herstellung
Prepared by a modification of the pepsin extraction and salt fractionation method of Niyibizi, C., et al., J. Biol. Chem., 259, 14170 (1984). It is an acid soluble collagen that can be dissolved in water with acetic acid added to pH 3.0 (5 mg/mL), yielding an opalescent, colorless solution.
Sonstige Hinweise
Kollagen wird in eine Reihe an strukturell und genetisch verschiedenen Typen unterteilt. Wir nutzen die Nomenklatur, die von Bornstein und Traub vorgeschlagen wurde. Achten Sie darauf, dass Sie die Typenbezeichnungen von Sigma nicht mit anerkannten Typenklassifizierungen von Kollagen verwechseln.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Kunden haben sich ebenfalls angesehen
Marta Biedzka-Sarek et al.
Infection and immunity, 76(11), 5016-5027 (2008-09-04)
Yersinia enterocolitica is an enteric pathogen that exploits diverse means to survive in the human host. Upon Y. enterocolitica entry into the human host, bacteria sense and respond to variety of signals, one of which is the temperature. Temperature in
Riina Harjumäki et al.
Scientific reports, 9(1), 7354-7354 (2019-05-16)
In vitro cell culture or tissue models that mimic in vivo cellular response have potential in tissue engineering and regenerative medicine, and are a more economical and accurate option for drug toxicity tests than animal experimentation. The design of in
Ria Aryani Hayuningtyas et al.
Molecular medicine (Cambridge, Mass.), 27(1), 125-125 (2021-10-05)
C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor 2 (DDR2) is activated by collagen
Yinglin Feng et al.
Frontiers in endocrinology, 12, 664766-664766 (2021-08-24)
Preeclampsia is a common obstetric disorder affecting 2-8% of pregnancy worldwide. Fibrosis is an important histological change occurring in preeclamptic placenta, and might depend on the excess deposition of collagen I. However, the role of fibrotic placenta and collagen I
Helen A Shaw et al.
Vaccines, 9(9) (2021-09-29)
Group A Streptococcus (GAS) is an important global human pathogen, with a wide range of disease presentations, from mild mucosal infections like pharyngitis to invasive diseases such as toxic shock syndrome. The effect on health and mortality from GAS infections
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung.