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C1655

Sigma-Aldrich

Choleratoxin-B-Untereinheit

FITC conjugate, lyophilized powder

Synonym(e):

CTB

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About This Item

MDL-Nummer:
MFCD02356522
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329774902
NACRES:
NA.77

Konjugat

FITC conjugate

Qualitätsniveau

200

Form

lyophilized powder

Mol-Gew.

~12 kDa

Zusammensetzung

Protein, ~20% Lowry

Kennzeichnungsgrad

~1.0 mol FITC per mol protein

Lagertemp.

2-8°C

SMILES String

CCOc1ccccc1C(=O)Nc2ccc(Cl)c(c2)C(F)(F)F

InChI

1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)

InChIKey

YDXZSNHARVUYNM-UHFFFAOYSA-N

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Anwendung

Cholera Toxin B subunit-fluorescein isothiocyanate (FITC) conjugate has been used as a fluorescent tracer:
  • to label distal cerebrospinal fluid-contacting neurons (dCSF-CNs) in lateral ventricles of rat
  • to stain epididymal sperms of mice
  • to stain peritoneal macrophages of mice

Biochem./physiol. Wirkung

Die Choleratoxin-B-Untereinheit wird in der neurologischen Forschung für das Track-Tracing verwendet; dies macht sich die GM1-Gangliosidbindung und den retrograden Transport zunutze. Mit Choleratoxin behandelte Gewebekulturzellen werden nicht abgetötet, und Gewebe von Tieren werden nicht nekrotisch.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Physikalische Form

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium EDTA and sodium azide

Hinweis zur Analyse

Activity measured by ELISA using ganglioside GM1 coated multiwell plates, rabbit anti-cholera toxin B subunit antibodies, and peroxidase-labeled goat anti-rabbit IgG as the second antibody. 50% saturation of binding was achieved with 0.01-1 μg of the cholera toxin B subunit-FITC conjugate per mL.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H332,H412

Gefahreneinstufungen

Acute Tox. 4 Inhalation - Aquatic Chronic 3

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Lindsey C Felix et al.
Aquatic toxicology (Amsterdam, Netherlands), 192, 58-68 (2017-09-18)
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Acta biomaterialia, 30, 49-61 (2015-11-26)
The surface modification of nanoparticles (NPs) can enhance the intracellular delivery of drugs, proteins, and genetic agents. Here we studied the effect of different surface ligands, including cell penetrating peptides (CPPs), on the cell binding and internalization of poly(lactic-co-glycolic) (PLGA)
Laura Aragoneses-Fenoll et al.
Journal of leukocyte biology (2021-02-03)
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Emily Igel et al.
The Journal of biological chemistry, 297(3), 101106-101106 (2021-08-24)
Polymorphisms in the apolipoprotein E (apoE) gene are risk factors for chronic inflammatory diseases including atherosclerosis. The gene product apoE is synthesized in many cell types and has both lipid transport-dependent and lipid transport-independent functions. Previous studies have shown that
Min Huang et al.
Oncology letters, 21(6), 438-438 (2021-04-20)
Pancreatic cancer is a highly malignant type of cancer and its treatment remains a major challenge. The novel recombinant protein TNF-related apoptosis-inducing ligand (TRAIL)-Mu3 has been shown to exert stronger tumor inhibitory effects in colon cancer in vitro and in
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