Fortfahren mit
C1413
Complement C7 deficient serum human
for complement assays
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 1 mL | Warenkorb auf Verfügbarkeit prüfen | € 260,00 |
Über diesen Artikel
NACRES:
NA.61
UNSPSC Code:
12352202
Biological source:
human
€ 260,00
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Unterstützung erhaltenApplication
Complement C7 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). C7 deficiencies in patients with meningococcal meningitis have shown a mutation which results in an 11 bp deletion in exon 6 resulting in a premature stop codon. Additionally, research has suggested that screening of patients with systemic neisserial infection by CH50 or the APH-50 assay can reveal a C7 deficiency.
Physical form
Supplied as a solution in PBS, pH 7.4
Analysis Note
C7 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Dieser Artikel | |||
|---|---|---|---|
| biological source human | biological source human serum | biological source human | biological source human |
| Gene Information human ... C7(730) | Gene Information human ... C7(730) | Gene Information human ... C6(729) | Gene Information human ... C2(717) |
| technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| form solution | form solution | form liquid | form liquid |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Lagerklasse
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sonia Barroso et al.
Immunology, 118(2), 257-260 (2006-06-15)
Different genetic mutations have been described in complement components resulting in total or subtotal deficiency states. In this work we report the genetic basis of C7 deficiency in a previously reported Spanish patient exhibiting a combined total deficiency of C7
Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
S??lzen, et al.
Nature Communications, 14, 2403-2403 (2023)
W P Kolb et al.
Journal of immunology (Baltimore, Md. : 1950), 122(5), 2103-2111 (1979-05-01)
C1q, a subcomponent of the first component of complement, has been isolated from human serum in fully hemolytically active form by affinity column chromatography and gel filtration with Bio-Gel A-5M. The affinity column was prepared by covalent coupling of purified
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C1413-1ML | 04061838162618 |