This product is the full-length, unmodified, native protein from human serum. Complement C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da.
C2787
Complement C7 from human serum
≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Über diesen Artikel
Form:
solution
Assay:
≥85% (SDS-PAGE)
Biological source:
human serum
Fortfahren mit
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenbiological source
human serum
Quality Level
assay
≥85% (SDS-PAGE)
form
solution
specific activity
≥150,000 C7H50 units/mg protein
concentration
1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2
technique(s)
activity assay: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... C7(730)
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) immunoelectrophoresis: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| assay ≥85% (SDS-PAGE) | assay ≥85% (SDS-PAGE) | assay ≥85% (SDS-GE) | assay - |
| biological source human serum | biological source human | biological source human | biological source human |
| concentration 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 | concentration - | concentration - |
| form solution | form solution | form solution | form liquid |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Biochem/physiol Actions
The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
Analysis Note
Functionally active by a sensitive hemolytic assay.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
A F Esser
Toxicology, 87(1-3), 229-247 (1994-02-28)
The membrane attack complex of complement is formed by the molecular fusion of the five terminal complement proteins, C5, C6, C7, C8, and C9. While the assembly process on a target membrane and its modulation by restriction factors present on
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2787-.1MG | 04061833484623 |
-
I would like to know if the product is a full sequence protein (92.4 kDa, 843 AA)?
1 answer-
Helpful?
-
Active Filters
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung