C1305

Cafestol acetate

≥98%

• Empirische Formel (Hill-System): C₂₂H₃₀O₄
• CAS-Nummer: 81760-48-7
• Molekulargewicht: 358.47
• NACRES: NA.79
• PubChem Substance ID: 24892399
• UNSPSC Code: 12352205
• MDL number: MFCD00133152

Eigenschaften

• Quality Segment: 100
• assay: ≥98%
• form: powder
• technique(s): HPLC: suitable
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: CC(=O)OCC1(O)CC23CCC4c5ccoc5CCC4(C)C2CCC1C3
• InChI: 1S/C22H30O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h7,10,15,17,19,24H,3-6,8-9,11-13H2,1-2H3
• InChI key: PTGGVIKFNQSFBY-UHFFFAOYSA-N

Beschreibung

Application

Cafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).

Biochem/physiol Actions

Cafestol is a coffee-specific diterpene. It has anti-carcinogenic and anti-inflammatory activities. Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage. Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.

Other Notes

Furan-containing diterpene from green coffee beans.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)