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A9106

Sigma-Aldrich

ADP-ribosylcyclase

1000-3000 units/mg protein

Synonym(e):

Adenosine diphosphoribose cyclase from Aplysia californica

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About This Item

CAS-Nummer:
135622-82-1
MDL-Nummer:
MFCD00212894
UNSPSC-Code:
12352204
NACRES:
NA.54

Biologische Quelle

(Aplysia californica)

Assay

≥80 μ protein/vial (BCA)

Form

lyophilized powder

Spezifische Aktivität

1000-3000 units/mg protein

Zusammensetzung

Protein, ≤10%

Verpackung

vial of ≥80 μg protein

Lagerbedingungen

dry at room temperature

Konzentration

≤10% (BCA method)

Eignung

suitable for enzyme test

Anwendung(en)

genomic analysis

Lagertemp.

−20°C

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Anwendung

ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

Biochem./physiol. Wirkung

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Einheitendefinition

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.

Physikalische Form

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H334

Gefahreneinstufungen

Resp. Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
Xiaojian Shao et al.
Nature protocols, 15(9), 2813-2836 (2020-08-05)
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap RNAs in a wide range of species. Identification
Nicholas D Peterson et al.
eLife, 11 (2022-02-01)
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis elegans Toll/interleukin-1 receptor domain protein
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