A5922

Amifostin Trihydrat

≥97% (TLC), powder

• Synonym(e): 2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
• Empirische Formel (Hill-System): C₅H₁₅N₂O₃PS · 3 H₂O
• CAS-Nummer: 112901-68-5
• Molekulargewicht: 268.27
• NACRES: NA.77
• PubChem Substance ID: 24278231
• UNSPSC Code: 12352200
• MDL number: MFCD00453866
• Assay: ≥97% (TLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• assay: ≥97% (TLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: OP(SCCNCCCN)(O)=O.O.O.O
• InChI: 1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
• InChI key: TXQPXJKRNHJWAX-UHFFFAOYSA-N

Beschreibung

Application

Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

Biochem/physiol Actions

Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves