A2731

AMG 9810

≥98% (HPLC), powder

• Synonym(e): 2E-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide
• Empirische Formel (Hill-System): C₂₁H₂₃NO₃
• CAS-Nummer: 545395-94-6
• Molekulargewicht: 337.41
• NACRES: NA.77
• PubChem Substance ID: 329770793
• UNSPSC Code: 12352203
• MDL number: MFCD00955103
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >5 mg/mL
• originator: Amgen
• storage temp.: 2-8°C
• SMILES string: CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
• InChI: 1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
• InChI key: GZTFUVZVLYUPRG-IZZDOVSWSA-N

Beschreibung

Biochem/physiol Actions

AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC₅₀ = 17 nM.

AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.

Features and Benefits

This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H413
• pcodes: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves