A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Synonym(e): 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Empirische Formel (Hill-System): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• CAS-Nummer: 160928-38-1
• Molekulargewicht: 785.05 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278252
• NACRES: NA.77
• MDL number: MFCD12910436
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: H₂O: >20 mg/mL, DMSO: insoluble
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• InChI key: UWMONIJVKGTUGE-OPKBHZIBSA-K
• Gene Information: human ... ENTPD2(954)

Beschreibung

General description

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39.[1] This ecto-ATPase inhibitor[2] is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.[1]

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

Application

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction[3]
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion[4]
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay[5]

Biochem/physiol Actions

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3