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A2169

Sigma-Aldrich

3′-Azido-3′-Desoxythymidin

≥98% (HPLC), powder, reverse transcriptase inhibitor

Synonym(e):

AZT, Azidothymidin, ZDV, Zidovudin

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25 MG
€ 109,00
100 MG
€ 339,00
250 MG
€ 656,00
1 G
€ 1.990,00

€ 109,00

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25 MG
€ 109,00
100 MG
€ 339,00
250 MG
€ 656,00
1 G
€ 1.990,00

About This Item

Empirische Formel (Hill-System):
C10H13N5O4
CAS-Nummer:
30516-87-1
Molekulargewicht:
267.24
Beilstein:
3595791
MDL-Nummer:
MFCD00006536
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278143
NACRES:
NA.77

€ 109,00

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Produktbezeichnung

3′-Azido-3′-Desoxythymidin, ≥98% (HPLC)

Assay

≥98% (HPLC)

Form

powder

mp (Schmelzpunkt)

113-115 °C (lit.)

Löslichkeit

H2O: 50 mg/mL

Lagertemp.

−20°C

SMILES String

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChIKey

HBOMLICNUCNMMY-XLPZGREQSA-N

Angaben zum Gen

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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Anwendung

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration[1] and as an antimicrobial agent to evaluate its anti-Salmonella activity.[2]

Biochem./physiol. Wirkung

Umkehrtranscriptase-Inhibitor aktiv gegen HIV-1-Viren
Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H341,H351

Gefahreneinstufungen

Carc. 2 - Muta. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

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