D1413

2′,3′-Didehydro-3′-Desoxythymidin

≥98% (TLC)

• Synonym(e): 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidin-2,4-(1H,3H)-dion, Stavudine
• Empirische Formel (Hill-System): C₁₀H₁₂N₂O₄
• CAS-Nummer: 3056-17-5
• Molekulargewicht: 224.21
• MDL-Nummer: MFCD00132921
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278356
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Lagertemp.: −20°C
• SMILES String: CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
• InChI: 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
• InChIKey: XNKLLVCARDGLGL-JGVFFNPUSA-N

Beschreibung

Allgemeine Beschreibung

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.[1]

Anwendung

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment.[2] It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity.[3] It has also been used in the preclinical evaluation of GS-9160.[4]

Biochem./physiol. Wirkung

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.[5]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)