A114

(+)-N-Allylnormetazocine hydrochloride

Name: (+)-N-Allylnormetazocine hydrochloride
Brand: SIGMA
Price: 448 EUR

≥98% (HPLC)

Synonym(e):

(+)-NANM hydrochloride, SKF-10047, SKF10047, [2S-(2α, 6α,11R*)]-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride

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10 MG

€ 448,00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₇H₂₃NO · HCl

CAS-Nummer:

133005-41-1

Molekulargewicht:

293.83

NACRES:

NA.77

PubChem Substance ID:

24278250

UNSPSC Code:

12352200

MDL number:

MFCD00078552

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]21/D +90.6°, c = 1 in ethanol(lit.)

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

storage condition

desiccated

color

white

solubility

H₂O: >10 mg/mL

storage temp.

room temp

SMILES string

Cl[H].C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C

InChI

1S/C17H23NO.ClH/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17;/h4-6,11-12,16,19H,1,7-10H2,2-3H3;1H/t12-,16+,17+;/m1./s1

InChI key

ZTGMHFIGNYXMJV-XSCGHNKWSA-N

Gene Information

human ... OPRS1(10280)

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Dieser Artikel	G3796	O0391	T3577
Sigma-Aldrich A114 (+)-N-Allylnormetazocine hydrochloride	Sigma-Aldrich G3796 Granisetron hydrochloride	Sigma-Aldrich O0391 Olopatadine hydrochloride	Sigma-Aldrich T3577 Tolperisone hydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form solid
drug control regulated under CDSA - not available from Sigma-Aldrich Canada	drug control -	drug control -	drug control -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
solubility H₂O: >10 mg/mL	solubility H₂O: >10 mg/mL	solubility H₂O: ≥20 mg/mL	solubility H₂O: >20 mg/mL

Biochem/physiol Actions

Selective σ₁ receptor agonist.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Pharmacological profiles of opioid ligands at kappa opioid receptors.

Parham Gharagozlou et al.

BMC pharmacology, 6, 3-3 (2006-01-26)

The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse kappa-opioid receptors. Receptor activation was assessed by measuring

Sigma receptor photolabeling and sigma receptor-mediated modulation of potassium channels in tumor cells.

R A Wilke et al.

The Journal of biological chemistry, 274(26), 18387-18392 (1999-06-22)

Recent work has indicated that sigma receptor ligands can modulate potassium channels. However, the only sigma receptor characterized at the molecular level has a novel structure unlike any other receptor known to modulate ion channels. This 26-kDa protein has a

Activity of opioid ligands in cells expressing cloned mu opioid receptors.

Parham Gharagozlou et al.

BMC pharmacology, 3, 1-1 (2003-01-07)

The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a cell system expressing only mu opioid receptors. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cyclic

sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures.

S Shimazu et al.

European journal of pharmacology, 388(2), 139-146 (2000-02-10)

We investigated the potential neuroprotective effects of several sigma receptor ligands in organotypic midbrain slice cultures as an excitotoxicity model system. When challenged with 100-microM N-methyl-D-aspartate (NMDA) for 24 h, dopaminergic neurons in midbrain slice cultures degenerated, and this was

Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites.

Y Itzhak

Life sciences, 42(7), 745-752 (1988-01-01)

The pharmacological specificity of representative psychotomimetic agents such as phencyclidine (PCP) analogs, opiate benzomorphans and several antipsychotic agents was assessed for the sigma and PCP binding sites. In a series of binding experiments, in rat brain membranes, sigma and PCP

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Global Trade Item Number

SKU	GTIN
A114-10MG	04061832555300

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(+)-N-Allylnormetazocine hydrochloride