![[Arg13] Amyloid-β-Protein Fragment 1-40 ≥80% (HPLC), lyophilized powder](/deepweb/assets/sigmaaldrich/product/images/132/249/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e/640/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e.jpg)
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Fortfahren mit
A1075
Amyloid β Protein Fragment 1-40
≥90% (HPLC), powder
Synonym(e):
Aβ40
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 0.1 mg | Warenkorb auf Verfügbarkeit prüfen | € 179,00 | |
| 0.5 mg | Warenkorb auf Verfügbarkeit prüfen | € 607,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C194H295N53O58S
CAS-Nummer:
Molekulargewicht:
4329.80
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
≥90% (HPLC)
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenGeneral description
Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.
Application
Amyloid β Protein Fragment 1-40 has been used:
- in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
- as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
- as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts[1]
Biochem/physiol Actions
Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.
Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.
Preparation Note
For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.
Other Notes
Lyophilized from 0.1% TFA in H2O
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| assay ≥90% (HPLC) | assay ≥90% (HPLC) | assay ≥80% (HPLC) | assay >97.0% |
| form powder | form powder | form lyophilized powder | form (Clear dry film) |
| Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. - |
| solubility 1% acetic acid: 1 mg/mL, saline: insoluble | solubility - | solubility H2O: soluble | solubility - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Verwandter Inhalt
Sandwich-Type Enzyme Immunoassay for Amyloid A4 Protein in Cerebrospinal Fluid From Patients with Head Trauma
PIRIM I
Turkish Journal of Medical Sciences, 31(1), 47-50 (2001)
Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
Mehta PD, et al.
Neuroscience Letters, 304(1-2), 102-106 (2001)
K Ueda et al.
Brain research, 639(2), 240-244 (1994-03-14)
The neurotoxic effects of soluble and aggregated synthetic amyloid beta protein (A beta P) have been investigated in rat primary cultures. Freshly solubilized beta(1-40) was neurotoxic not to immature, but to mature hippocampal neurons. On the other hand, aggregated beta(1-40)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A1075-.5MG | 04061833334836 |
| A1075-.1MG | 04061833334782 |
-
What is the Department of Transportation shipping information for this product?
1 answer-
Helpful?
-
-
This product has a temperature storage of -20 C on the label, but the material did not come on ice. Is the product still good?
1 answer-
Where there may short-term exposure (I.e. during shipment) to conditions other than those recommended for long-term storage that will not affect product quality, Sigma-Aldrich will ship at ambient temperature.
Helpful?
-
-
Which document(s) contains shelf-life or expiration date information for a given product?
1 answer-
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
Helpful?
-