A0835

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

• Synonym(e): Ac-DEVD-CHO
• Empirische Formel (Hill-System): C₂₀H₃₀N₄O₁₁
• CAS-Nummer: 169332-60-9
• Molekulargewicht: 502.47
• NACRES: NA.32
• PubChem Substance ID: 24890193
• UNSPSC Code: 12352209
• MDL number: MFCD00671412

Eigenschaften

• biological source: synthetic
• Quality Segment: 100
• assay: ≥95%
• form: powder
• color: white
• solubility: H₂O: 1 mg/mL
• storage temp.: −20°C
• SMILES string: [H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C
• InChI: 1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)
• InChI key: UMBVAPCONCILTL-UHFFFAOYSA-N
• Gene Information: human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)

Beschreibung

General description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.[1]

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples,[2] smooth muscle cells[3] and Jurkat T-cells.[4]

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.[1]

Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)