The solubility of this product is not analyzed on a lot-to-lot basis. The compound is expected to be soluble in water at 0.4 mg/ml, ethanol at 2.6 mg/ml, methanol at 12.1 mg/ml, chloroform at 22.2 mg/ml, and DMSO at 50 mg/ml.
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Trimethoprim
≥99.0% (HPLC)
Synonym(e):
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidin, NSC 106568
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1 G
€ 49,90
5 G
€ 174,00
25 G
€ 683,00
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1 G
€ 49,90
5 G
€ 174,00
25 G
€ 683,00
About This Item
Empirische Formel (Hill-System):
C14H18N4O3
CAS-Nummer:
Molekulargewicht:
290.32
Beilstein:
625127
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
51285203
PubChem Substanz-ID:
NACRES:
NA.85
Empfohlene Produkte
Biologische Quelle
synthetic
Qualitätsniveau
Assay
≥99.0% (HPLC)
Form
powder
Farbe
white to light yellow
mp (Schmelzpunkt)
≥199.0 °C
Wirkungsspektrum von Antibiotika
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
Wirkungsweise
DNA synthesis | interferes
enzyme | inhibits
Lagertemp.
2-8°C
SMILES String
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChIKey
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Angaben zum Gen
human ... DHFRP1(573971) , KCNH1(3756)
rat ... Dhfr(24312)
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Allgemeine Beschreibung
Chemical structure: pyrimidine
Anwendung
Antibakterieller Wirkstoff, Dihydrofolatreduktase-Inhibitor mit Selektivität für prokaryotische Enzyme.
Biochem./physiol. Wirkung
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Verpackung
1g,5g,25g
Sonstige Hinweise
Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral - Repr. 2
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Analysenzertifikate (COA)
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Is Trimethoprim soluble in DMSO or water?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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