Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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46984
Trimethoprim
VETRANAL®, analytical standard
Synonym(e):
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidin, NSC 106568
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 250 mg | Warenkorb auf Verfügbarkeit prüfen | € 68,10 |
Über diesen Artikel
Empirische Formel (Hill-System):
C14H18N4O3
CAS-Nummer:
Molekulargewicht:
290.32
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
212-006-2
Beilstein/REAXYS Number:
625127
MDL number:
Technischer Dienst
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Unterstützung erhaltengrade
analytical standard
Quality Segment
agency
EPA 1694
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
application(s)
clinical testing
format
neat
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key
IEDVJHCEMCRBQM-UHFFFAOYSA-N
General description
Chemical structure: pyrimidine
Application
Antibakterieller Wirkstoff, Dihydrofolatreduktase-Inhibitor mit Selektivität für prokaryotische Enzyme.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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Dieser Artikel | |||
|---|---|---|---|
| application(s) clinical testing | application(s) - | application(s) forensics and toxicology | application(s) pharmaceutical (small molecule) |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| format neat | format - | format neat | format neat |
| Quality Level 100 | Quality Level 200 | Quality Level 300 | Quality Level 300 |
| grade analytical standard | grade - | grade certified reference material, TraceCERT® | grade certified reference material, pharmaceutical secondary standard |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-30°C |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M Grape et al.
Antimicrobial agents and chemotherapy, 51(5), 1863-1864 (2007-02-20)
Two Escherichia coli isolates resistant to trimethoprim but negative for integrons carried two new resistance genes, dfrA24 and dfrA26, remotely similar to one another and to the cassette-independent genes dfrA8 and dfrA9. The dfrA24 gene was not associated with known
Christine Manyando et al.
PloS one, 9(5), e96017-e96017 (2014-05-17)
Antibiotic therapy during pregnancy may be beneficial and impacts positively on the reduction of adverse pregnancy outcomes. No studies have been done so far on the effects of daily Co-trimoxazole (CTX) prophylaxis on birth outcomes. A phase 3b randomized trial
Karin Tegmark Wisell et al.
The Journal of antimicrobial chemotherapy, 62(1), 35-40 (2008-04-15)
The lack of oral treatment alternatives for enterococcal urinary tract infections (UTIs) has led to a renewed interest in trimethoprim. Enterococci can incorporate exogenously produced folates and thereby reverse the effect of trimethoprim. Although a large proportion of enterococci appear
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 46984-250MG | 04061832359168 |
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Is Trimethoprim stable in solution?
1 answer-
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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