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Sigma-Aldrich

Voglibose

≥97.0% (TLC)

Synonym(e):

3,4-Dideoxy-4-{[2-hydroxy-1-(hydroxymethyl)-ethyl]-amino]-2-D-epi-inosit, N-(1,3-Dihydroxyprop-2-yl)-valiolamin

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About This Item

Empirische Formel (Hill-System):
C10H21NO7
CAS-Nummer:
83480-29-9
Molekulargewicht:
267.28
MDL-Nummer:
MFCD00865496
UNSPSC-Code:
12352201
PubChem Substanz-ID:
329757591
NACRES:
NA.25

Biologische Quelle

synthetic

Assay

≥97.0% (TLC)

Form

powder

Farbe

white

Lagertemp.

−20°C

SMILES String

OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1

InChIKey

FZNCGRZWXLXZSZ-CIQUZCHMSA-N

Angaben zum Gen

human ... GAA(2548) , MGAM(8972) , MGAM2(93432) , SI(6476)

Anwendung

Voglibose is an α-glucosidase inhibitor, similar to acarbose and miglitol, used for lowering post-prandial hyperglycemia (PPHG) in people with diabetes mellitus. Voglibose is used to study it benefits as a protectant against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sonstige Hinweise

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Xiaolong Chen et al.
Current medicinal chemistry, 13(1), 109-116 (2006-02-07)
The number of people with diabetes is expected to rise from the current estimated 150 million to 220 million in 2010 and 300 million in 2025, and 90% is Type 2 diabetes or non-insulin dependent diabetes mellitus (NIDDM). Voglibose, one
Devasier Bennet et al.
International journal of nanomedicine, 7, 3399-3419 (2012-08-14)
Antioxidant (quercetin) and hypoglycemic (voglibose) drug-loaded poly-D,L-lactideco-glycolide nanoparticles were successfully synthesized using the solvent evaporation method. The dual drug-loaded nanoparticles were incorporated into a scaffold film using a solvent casting method, creating a controlled transdermal drug-delivery system. Key features of
Y Iwamoto et al.
Diabetes, obesity & metabolism, 12(7), 613-622 (2010-07-02)
To compare the efficacy and safety of sitagliptin (a dipeptidyl peptidase-4 inhibitor) and voglibose (an alpha-glucosidase inhibitor) monotherapy in Japanese patients with type 2 diabetes who have inadequate glycaemic control (HbA1c > or =6.5% and <10.0%) on diet and exercise.
R Kawamori et al.
Diabetes, obesity & metabolism, 14(4), 348-357 (2011-12-08)
To evaluate the efficacy and safety of linagliptin 5 and 10 mg vs. placebo and voglibose in Japanese patients with type 2 diabetes mellitus (T2DM). This study enrolled patients with inadequately controlled T2DM who were previously treated with one or
Y Iwamoto et al.
Diabetes, obesity & metabolism, 12(8), 700-708 (2010-07-02)
To confirm the efficacy of vildagliptin in patients with type 2 diabetes (T2D) by testing the hypothesis that glycosylated haemoglobin (HbA1c) reduction with vildagliptin is superior to that with voglibose after 12 weeks of treatment. In this 12-week, randomized, double-blind
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