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Sigma-Aldrich

4-Hydroxy-L-isoleucin

≥98.0% (TLC)

Synonym(e):

(2S,3R)-2-Amino-4-hydroxy-3-methyl-pentansäure

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About This Item

Empirische Formel (Hill-System):
C6H13NO3
CAS-Nummer:
781658-23-9
Molekulargewicht:
147.17
MDL-Nummer:
MFCD06799350
UNSPSC-Code:
12352204
eCl@ss:
32160406
PubChem Substanz-ID:
329757475
NACRES:
NA.32

product name

4-Hydroxy-L-isoleucin, ≥98.0% (TLC)

Assay

≥98.0% (TLC)

Optische Aktivität

[α]/D +34.0±2.0°, c = 1 in H2O

Farbe

white to off-white

Lagertemp.

2-8°C

SMILES String

CC(O)[C@H](C)[C@H](N)C(O)=O

InChI

1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4?,5-/m0/s1

InChIKey

OSCCDBFHNMXNME-DSDZBIDZSA-N

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Biochem./physiol. Wirkung

A peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity; effects on insulin secretion, plant-derived treatment for metabolic syndrome.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

296.6 °F

Flammpunkt (°C)

147 °C

Analysenzertifikate (COA)

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Choong Tat Keng et al.
Gut, 65(10), 1744-1753 (2015-07-08)
HCV infection affects millions of people worldwide, and many patients develop chronic infection leading to liver cancers. For decades, the lack of a small animal model that can recapitulate HCV infection, its immunopathogenesis and disease progression has impeded the development
Anna Maria Herzner et al.
PloS one, 6(7), e22389-e22389 (2011-08-04)
Lantibiotics are small peptide antibiotics that contain the characteristic thioether amino acids lanthionine and methyllanthionine. As ribosomally synthesized peptides, lantibiotics possess biosynthetic gene clusters which contain the structural gene (lanA) as well as the other genes which are involved in
Jasmin Dischinger et al.
PloS one, 4(8), e6788-e6788 (2009-08-27)
Lantibiotics are small microbial peptide antibiotics that are characterized by the presence of the thioether amino acids lanthionine and methyllanthionine. Lantibiotics possess structural genes which encode inactive prepeptides. During maturation, the prepeptide undergoes posttranslational modifications including the introduction of rare
C Broca et al.
European journal of pharmacology, 390(3), 339-345 (2000-03-10)
4-Hydroxyisoleucine, a peculiar amino acid extracted from fenugreek seeds and never found in mammalian tissues, exhibits interesting insulinotropic activity. To investigate the structural requirements for this stimulating effect, the insulinotropic activity of the major isomer (2S,3R,4S) of 4-hydroxyisoleucine, in the
Zhi Zhang et al.
PloS one, 8(4), e62909-e62909 (2013-05-03)
Natural populations of the fruit fly, Drosophila melanogaster, segregate genetic variation that leads to cardiac disease phenotypes. One nearly isogenic line from a North Carolina peach orchard, WE70, is shown to harbor two genetically distinct heart phenotypes: elevated incidence of
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