(±)-Homocitronensäure Trinatriumsalz

Name: (±)-Homocitronensäure Trinatriumsalz
Brand: SIGMA

Synonym(e):

2-Hydroxy-1,2,4-butantricarbonsäure Trinatriumsalz, Natriumhomocitrat tribasisch

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Über diesen Artikel

Empirische Formel (Hill-System):

C₇H₇Na₃O₇

Molekulargewicht:

272.10

NACRES:

NA.25

PubChem Substance ID:

329757376

UNSPSC Code:

12352106

MDL number:

MFCD16875434

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Unterstützung erhalten

impurities

≤15.0% water

Quality Level

100

SMILES string

[Na+].[Na+].[Na+].OC(CCC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C7H10O7.3Na/c8-4(9)1-2-7(14,6(12)13)3-5(10)11;;;/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3

InChI key

SNTBDRNHMPWDFS-UHFFFAOYSA-K

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Dieser Artikel	25114	71405
Sigma-Aldrich 48488 Sodium (±)-homocitrate tribasic	Sigma-Aldrich 25114 Sodium citrate tribasic hydrate	71405 Sodium citrate tribasic dihydrate
Quality Level 100	Quality Level 200	Quality Level 200
impurities ≤15.0% water	impurities ≤0.001% heavy metals (as Pb), ≤0.04% free alkali (as NaOH), ≤0.06% free acid (as C₆H₈O₇)	impurities 11-13% water (KFT)

Application

Sodium (±)-homocitrate tribasic may be used in studies of formation and function of the iron-molybdenum cofactor (FeMo-co) which contains 7Fe, 9S, Mo, R-homocitrate. FeMo-co is essential for nitrogen fixation by nitrogenous organisms.

Biochem/physiol Actions

Component of the iron-molybdenum cofactor of nitrogenases[1] [2], essential isomerization of homocitrate via homoaconitate to homoisocitrate[3], homocitrate accumulation seems to act as a sensor of lysine-pathway distress[4].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

BCBH7814V

BCBB2860V

BCBB2860

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Identification of the V factor needed for synthesis of the iron-molybdenum cofactor of nitrogenase as homocitrate.

T R Hoover et al.

Nature, 329(6142), 855-857 (1987-10-04)

Nitrogenase catalyses the ATP-dependent reduction of N2 to NH3, and is composed of two proteins, dinitrogenase (MoFe protein or component I) and dinitrogenase reductase (Fe protein or component II). Dinitrogenase contains a unique prosthetic group (iron-molybdenum cofactor, FeMoco) comprised of

Large scale isolation and characterization of the molybdenum-iron cluster from nitrogenase.

L Ma et al.

The Journal of biological chemistry, 269(27), 18007-18015 (1994-07-08)

Here we report the large scale isolation and characterization of a species, designated MoFe cluster, that exhibits an S = 3/2 EPR signal, and the comparison of this entity to isolated FeMo cofactor in N-methylformamide and to the active site

Homocitrate is a component of the iron-molybdenum cofactor of nitrogenase.

T R Hoover et al.

Biochemistry, 28(7), 2768-2771 (1989-04-04)

When apodinitrogenase (lacking FeMo-co) was activated with FeMo-co synthesized in vitro in the presence of 3H-labeled homocitrate, label was incorporated into dinitrogenase. The physical association of the label with FeMo-co was demonstrated by reisolation and purification of the cofactor from

Substrate reduction properties of dinitrogenase activated in vitro are dependent upon the presence of homocitrate or its analogues during iron-molybdenum cofactor synthesis.

J Imperial et al.

Biochemistry, 28(19), 7796-7799 (1989-09-19)

(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid [(R)-homocitrate] has been has been recently reported to be an integral constituent of the otherwise thought to be inorganic iron-molybdenum cofactor of dinitrogenase [Hoover, T.R., Imperial, J., Ludden, P.W., & Shah, V.K. (1989) Biochemistry 28,2768-2771]. Different organic acids

Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.

Franco Teves et al.

Microbiology (Reading, England), 155(Pt 12), 3881-3892 (2009-08-22)

The lysine biosynthetic pathway has to supply large amounts of alpha-aminoadipic acid for penicillin biosynthesis in Penicillium chrysogenum. In this study, we have characterized the P. chrysogenum L2 mutant, a lysine auxotroph that shows highly increased expression of several lysine

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