This product is not sterile. The solution may be filter-sterilized, however gravity or very low pressure is recommended, as strong positive or negative pressure during the filtration process may cause precipitation. Note that this product has not been tested for use in cell culture.
Fortfahren mit
15862
Cobaltchlorid 0,1 mol/l -Lösung
Synonym(e):
Cobalt(II)-chlorid -Lösung, Additiv Screening-Lösung 24/Kit.-Nr. 78374
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Über diesen Artikel
CAS-Nummer:
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352302
MDL number:
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
Technischer Dienst
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Unterstützung erhaltenQuality Segment
density
1.01 g/mL at 20 °C
storage temp.
2-8°C
SMILES string
Cl[Co]Cl
InChI
1S/2ClH.Co/h2*1H;/q;;+2/p-2
InChI key
GVPFVAHMJGGAJG-UHFFFAOYSA-L
Application
Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells.
Biochem/physiol Actions
Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.
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| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| density 1.01 g/mL at 20 °C | density - | density - | density - |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. - |
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Carc. 1B - Repr. 1B
Lagerklasse
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Zulassungslistungen
Zulassungslistungen werden hauptsächlich für chemische Produkte erstellt. Für nicht-chemische Produkte können hier nur begrenzte Angaben gemacht werden. Kein Eintrag bedeutet, dass keine der Komponenten gelistet ist. Es liegt in der Verantwortung des Benutzers, die sichere und legale Verwendung des Produkts zu gewährleisten.
7646-79-9
CAS No.
7646-79-9
CAS No.
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Francesca Lazzara et al.
Frontiers in pharmacology, 11, 1063-1063 (2020-08-28)
Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial
Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans.
Wojtal KA, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307, G673-G673 (2014)
Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells.
Wang G, et al.
Nucleic Acids Research, 28, 2135-2135 (2000)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 15862-1ML-F | 04061838744081 |
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Is this product sterile?
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How long can this be stored for at 2-8 degrees?
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This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services
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