33894

Clotrimazol

VETRANAL^®, analytical standard

• Synonym(e): 1-(o-Chlor-α,α-diphenylbenzyl)-imidazol, 1-(o-Chlortrityl)-imidazol, 1-[(2-Chlorphenyl)-diphenylmethyl]-1H-imidazol
• Empirische Formel (Hill-System): C₂₂H₁₇ClN₂
• CAS-Nummer: 23593-75-1
• Molekulargewicht: 344.84
• NACRES: NA.24
• PubChem Substance ID: 329754531
• UNSPSC Code: 41116107
• EC Number: 245-764-8
• MDL number: MFCD00057220

Eigenschaften

• grade: analytical standard
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• antibiotic activity spectrum: fungi
• application(s): agriculture; environmental
• format: neat
• mode of action: protein synthesis | interferes
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI key: VNFPBHJOKIVQEB-UHFFFAOYSA-N

Beschreibung

General description

Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.

Application

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H315,H319,H410
• pcodes: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves