27102

Citronensäure Monohydrat

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

• Synonym(e): 2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
• Lineare Formel: HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS-Nummer: 5949-29-1
• Molekulargewicht: 210.14
• UNSPSC Code: 12352100
• NACRES: NA.21
• PubChem Substance ID: 57648219
• EC Number: 201-069-1
• Beilstein/REAXYS Number: 4018641
• MDL number: MFCD00149972
• Assay: 99.5-100.5% (based on anhydrous substance)
• Form: grit

Eigenschaften

• grade: puriss.
• Quality Segment: 200
• assay: 99.5-100.5% (based on anhydrous substance)
• form: grit
• quality: meets analytical specification of Ph. Eur., BP, USP, E330
• impurities: residual solvents, complies, ≤0.0005% heavy metals (as Pb), 7.5-8.8% water (Karl Fischer)
• ign. residue: ≤0.05% (as SO₄)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• anion traces: chloride (Cl^-): ≤50 mg/kg, oxalate (as oxalic acid): ≤100 mg/kg, sulfate (SO₄^2-): ≤100 mg/kg
• cation traces: As: ≤1 mg/kg, Ca: ≤200 mg/kg, Cu: ≤10 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, Pb: ≤1 mg/kg, Zn: ≤10 mg/kg
• suitability: complies for appearance of solution, complies for identity (IR), complies for reaction against H₂SO₄
• functional group: carboxylic acid
• SMILES string: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• InChI key: YASYEJJMZJALEJ-UHFFFAOYSA-N

Beschreibung

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be Δ_solH_m (298.15K, m = 0.0203molkg^-1) = (29061 ± 123)Jmol^-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix.[1] It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.[2]

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H335
• pcodes: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: 345.0 °F - closed cup
• flash_point_c: 173.9 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves