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Merck

03738

Supelco

5-Fluorouracil

analytical standard

Synonym(e):

2,4-Dihydroxy-5-Fluoropyrimidin, 5-FU, 5-Fluor-2,4(1H,3H)-pyrimidindion

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About This Item

Empirische Formel (Hill-System):
C4H3FN2O2
CAS-Nummer:
Molekulargewicht:
130.08
Beilstein:
127172
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥99.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Verunreinigungen

≤0.5% water

mp (Schmelzpunkt)

282-286 °C (dec.) (lit.)

Anwendung(en)

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

Format

neat

SMILES String

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChIKey

GHASVSINZRGABV-UHFFFAOYSA-N

Angaben zum Gen

human ... TYMS(7298)

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Allgemeine Beschreibung

5-Fluorouracil is an anti-tumor agent, widely used in the treatment of various malignancies.

Anwendung

5-Fluorouracil may be used as an analytical standard for the determination of the analyte in hospital effluents by capillary electrophoresis, and in biological samples and environmental samples by chromatography based techniques.

Piktogramme

Skull and crossbonesHealth hazard

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Acute Tox. 3 Oral - Carc. 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


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Kunden haben sich ebenfalls angesehen

Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
Carethers JM, et al.
Gastroenterology, 126(2), 394-401 (2004)
5-fluorouracil: mechanisms of action and clinical strategies
Longley DB, et al.
Nature Reviews. Cancer, 3(5), 330-338 (2003)
A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography.
A R Buckpitt et al.
Analytical biochemistry, 106(2), 432-437 (1980-08-01)
G Micoli et al.
Journal of chromatography. B, Biomedical sciences and applications, 750(1), 25-32 (2001-02-24)
5-Fluorouracil (5-FU) is one of the most widely used antineoplastic drugs. It can be therefore considered to be a model compound for the identification of exposure routes during preparation and administration of cytostatic agents, especially for nucleoside analogue drugs. In
Susanne N Mahnik et al.
Analytical and bioanalytical chemistry, 380(1), 31-35 (2004-09-15)
Cytostatic anticancer drugs are an increasingly important issue in the environmental debate, mainly due to the lack of knowledge about the fate of these toxic substances. Over the last decades, 5-fluorouracil (5-FU) has been one of the most frequently used

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