MABE952
Anti-Histone H3.1 Antibody
rat monoclonal, 1D4F2
Synonym(e):
Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l
Größe auswählen
| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 μg | Warenkorb auf Verfügbarkeit prüfen | € 506,00 |
Über diesen Artikel
€ 506,00
Produktname
Anti-Histon-H3.1-Antikörper, Klon 1D4F2, clone 1D4F2, 1 mg/mL, from rat
biological source
rat
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
1D4F2, monoclonal
species reactivity
human, mouse
concentration
1 mg/mL
technique(s)
ChIP: suitable (ChIP-seq), immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... HIST1H3F(8968)
General description
Immunogen
Application
Immunzytochemische Analyse: Mit einer 1:2.000-Verdünnung einer repräsentativen Charge wurde Histon H3.1 in NIH/3T3-Zellen nachgewiesen (Prof. Taro Tachibana, Cell Engineering Corporation).
Alexa Fluor™ ist eine eingetragene Marke von Life Technologies.
Immunpräzipitationsanalyse: Mit einer repräsentativen Charge aus einem unabhängigen Labor wurde Histon H3.1 in C2C12-Zellen nachgewiesen (Harada, A., et al. (2012). EMBO J. 31(13):2994–3007.).
Analyse mittels Chromatin-Immunpräzipitation: Mit einer repräsentativen Charge aus einem unabhängigen Labor wurde eine Immunpräzipitation von Histon H3.1 durchgeführt (Maehara, K., et al. (2013). Nucleic Acids Res. 41(1):54–62.).
Sequenzierungsanalyse mittels Chromatin-Immunpräzipitation: Mit einer repräsentativen Charge aus einem unabhängigen Labor wurde eine Immunpräzipitation von Histon H3.1 durchgeführt (Maehara, K., et al. (2013). Nucleic Acids Res. 41(1):54–62.).
Physical form
Analysis Note
Western-Blot-Analyse: Mit 1 µg/ml dieses Antikörpers wurde Histon H3.1 in 10 µg HeLa-Säureextrakt nachgewiesen.
Legal Information
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| antibody form purified antibody | antibody form purified immunoglobulin | antibody form affinity isolated antibody | antibody form purified antibody |
| biological source rat | biological source rat | biological source rabbit | biological source rat |
| Gene Information human ... HIST1H3F(8968) | Gene Information human ... HIST1H3F(8968) | Gene Information human ... HIST1H3F(8968) | Gene Information human ... HIST1H3F(8968) |
| clone 1D4F2, monoclonal | clone 5D10D4, monoclonal | clone polyclonal | clone 6C7G12, monoclonal |
| species reactivity human, mouse | species reactivity human | species reactivity human, mouse, rat | species reactivity human |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
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Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
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Verwandter Inhalt
Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABE952 | 04053252975691 |