EI3

Antipain

Inhibitor of papain, trypsin and plasmin

• UNSPSC Code: 51111800
• NACRES: NA.77
• eCl@ss: 32160405
• Quality level: 100

Eigenschaften

• Produktname: Antipain,
• manufacturer/tradename: Chemicon^®
• Quality Level: 100
• shipped in: dry ice

Beschreibung

General description

Antipain is known for regulating the number of chromosomal aberrations caused by the S-phase-dependent alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine. It can also diminish the nuclear binding of the estrogen-receptor complex in MCF-7 breast tumor cells.

Application

Antipain has been used in microfluidic chip assay.

Biochem/physiol Actions

Inhibitor Type: Protease Inhibitors

Physical form

Lyophilized no preservatives.

Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.

Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.

Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.

Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.

Preparation Note

Maintain dry at -20ºC for up to 18 months. Store reconstituted product in aliquots at -20ºC for up to 9 months. Do not thaw and refreeze.

Analysis Note

pH 1% aqueous solution: 5.2

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable