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AB2203

Anti-CLOCK Antibody

Name: Anti-CLOCK Antibody
Brand: MM
Price: 463 EUR

serum, Chemicon^®

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Packungsgröße	SKU	Verfügbarkeit	Preis
100 μL		Warenkorb auf Verfügbarkeit prüfen	€ 463,00

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

€ 463,00

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Unterstützung erhalten

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon^®

technique(s)

western blot: suitable

GenBank accession no.

AAC53200

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Dieser Artikel	ABE2598M	SAB5701638	AB5416P
Sigma-Aldrich AB2203 Anti-CLOCK Antibody	Sigma-Aldrich ABE2598M Anti-CLOCK	Sigma-Aldrich SAB5701638 Anti-CLOCK antibody produced in rabbit	Sigma-Aldrich AB5416P Anti-Clock Antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form serum	antibody form affinity isolated antibody	antibody form -	antibody form affinity purified immunoglobulin
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source guinea pig	biological source rabbit	biological source rabbit
shipped in wet ice	shipped in -	shipped in wet ice	shipped in dry ice
Gene Information mouse ... Clock(12753)	Gene Information mouse ... Clock(12753)	Gene Information human ... CLOCK(9575)	Gene Information human ... CLOCK(9575)

General description

Approx. 95 kDa

Circadian Locomotor Output Cycles Kaput, or Clock is a gene which encodes proteins regulating circadian rhythm. This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like protein to activate transcription of mouse period 1.

Application

Anti-CLOCK Antibody is an antibody against CLOCK for use in WB.

Western Blot Analysis:
L6 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-CLOCK (1:500 dilution of this lot).
Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.

Biochem/physiol Actions

Cat. # AB2203 recognizes CLOCK protein

Reactivity with other species has not been tested.

Analysis Note

Control
L6 Cell Lysate.

Routinely evaluated by western blot on L6 tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

GenBank is a registered trademark of United States Department of Health and Human Services

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Lagerklasse

10 - Combustible liquids

wgk

WGK 1

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.

LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR

Testing null

Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model.

Mark A Naven et al.

Theranostics, 12(8), 3963-3976 (2022-06-07)

The circadian clock in murine articular cartilage is a critical temporal regulatory mechanism for tissue homeostasis and osteoarthritis. However, translation of these findings into humans has been hampered by the difficulty in obtaining circadian time series human cartilage tissues. As

Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina.

Xiaoqin Liu et al.

PloS one, 7(11), e50602-e50602 (2012-11-29)

Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein products. In the mammalian

Clock genes control cortical critical period timing.

Yohei Kobayashi et al.

Neuron, 86(1), 264-275 (2015-03-25)

Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of

SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker.

Arthur H Cheng et al.

Cell reports, 26(12), 3191-3202 (2019-03-21)

Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other transcription factors outside of the circadian TTFLs to the functionality of the SCN

Global Trade Item Number

SKU	GTIN
AB2203	04053252278365

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