AB1555
Anti-NMDAR2A-Antikörper
serum, Chemicon®
Synonym(e):
Anti-EPND, Anti-GluN2A, Anti-LKS, Anti-NMDAR2A, Anti-NR2A
Größe auswählen
| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 50 μL | Warenkorb auf Verfügbarkeit prüfen | € 453,00 |
Über diesen Artikel
€ 453,00
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
fish, human, rat, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
suitability
not suitable for immunohistochemistry
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GRIN2A(2903)
Immunogen
Application
Neurowissenschaft
Neurotransmitter & Rezeptoren
* Siehe empfohlenes Protokoll
Immunpräzipitation unter Verwendung solubilisierter Hippocampus-Schnitte. 3 μl fällen mittels Immunpräzipitation (unter geeigneten Bedingungen) sämtliches NMDAR2A in 200 μg Rattenhirn quantitativ aus.
Nicht empfohlen für die Verwendung in der Immunhistochemie.
Optimale Arbeitsverdünnungen müssen vom Endanwender bestimmt werden.
Biochem/physiol Actions
Physical form
Preparation Note
Analysis Note
NMDAR2A ist im Hippocampus in hohen Konzentrationen vorhanden.
Legal Information
Disclaimer
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form serum | antibody form affinity isolated antibody | antibody form affinity purified immunoglobulin | antibody form purified immunoglobulin |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source mouse |
| shipped in dry ice | shipped in wet ice | shipped in dry ice | shipped in wet ice |
| species reactivity fish, human, rat, mouse | species reactivity human | species reactivity rat | species reactivity mouse, human, rat |
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Lagerklasse
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
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Verwandter Inhalt
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB1555 | 04053252363801 |