681625

W-5, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

• Synonym(e): W-5, Hydrochloride, N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
• Empirische Formel (Hill-System): C₁₆H₂₂N₂O₂S · xHCl
• CAS-Nummer: 61714-25-8
• Molekulargewicht: 306.42 (free base basis)
• MDL number: MFCD00058043
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (NMR)
• Form: crystalline solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Eigenschaften

• Quality Level: 100
• assay: ≥98% (NMR)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• solubility: DMSO: soluble, water: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(NCCCCCCN)c1c2c(ccc1)cccc2.[Cl-].[H+]
• InChI: 1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
• InChI key: HOCSVIGHWPLMFC-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM) and myosin light chain kinase (IC₅₀ = 230 µM).

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 230 &microM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable