5.05145

(+)-Tubocurarine Chloride

• Synonym(e): (+)-Tubocurarine Chloride, Nicotinic Acetylcholine Receptor Antagonist, (+)-Tubocurarine chloride, D-tubocurarine, DTC
• Empirische Formel (Hill-System): C₃₇H₄₂Cl₂N₂O₆
• CAS-Nummer: 57-94-3
• Molekulargewicht: 681.65
• MDL number: MFCD00013471
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: H₂O: soluble
• storage temp.: −20°C
• SMILES string: [Cl-].[Cl-].[N+]1([C@@H]2Cc3cc(c(cc3)O)Oc4cc5c(cc4OC)CC[N+H]([C@H]5Cc6ccc(cc6)Oc7c2c(cc(c7O)OC)CC1)C)(C)C
• InChI: 1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1
• InChI key: GXFZCDMWGMFGFL-KKXMJGKMSA-N

Beschreibung

General description

A potent competitive antagonist of nAChR (IC50= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

Biochem/physiol Actions

Primary Target
nAch

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warming is required for complete solubilization.

Other Notes

Bowman, C., 2006. Br. J. Pharmacol.147, S277.
Wenningmann, I., et al. 2001. Mol. Pharmacol.60, 790.
Pederson, X., 1990. Proc. Natl. Acad. Sci. USA.87, 2785.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials