The isomer ratio of product 495455 has not been determined. It is known that the total (A+B+C) is greater than or equal to 90 percent.
495455
Oligomycin
≥90% (mixture of A, B, and C isomers, HPLC), powder, Antibiotic, Calbiochem
Synonym(e):
Oligomycin
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 10 mg | Warenkorb auf Verfügbarkeit prüfen | € 170,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C45H74O11
CAS-Nummer:
Molekulargewicht:
791.06
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (mixture of A, B, and C isomers, HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze
€ 170,00
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Technischer Dienst
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Unterstützung erhaltenProduktname
Oligomycin, A mixture of A, B, and C isomers.
Quality Level
assay
≥90% (mixture of A, B, and C isomers, HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
shipped in
ambient
storage temp.
−20°C
InChI
1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
Verwandte Kategorien
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| assay ≥90% (mixture of A, B, and C isomers, HPLC) | assay ≥99% (HPLC) | assay ≥90% total oligomycins basis (HPLC) | assay ≥90% (HPLC) |
| form powder | form powder | form powder | form film |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition OK to freeze | storage condition - | storage condition - | storage condition OK to freeze, protect from light |
General description
Mischung aus A-, B- und C-Isomeren. Makrolidantibiotikum, das die membrangebundene mitochondriale ATP-Synthase hemmt und so die Übertragung der Phosphorylgruppe verhindert. Induziert die Apoptose in kultivierten menschlichen Lymphoblastoidzellen und anderen Säugerzellen.
Biochem/physiol Actions
Primärziel
Membrangebundene mitochondriale ATPase (F1)
Membrangebundene mitochondriale ATPase (F1)
Produkt konkurriert nicht mit ATP.
Reversibel: nein
Zellpermeabel: nein
Preparation Note
Nach der Rekonstitution in Aliquote aufteilen und einfrieren (-20 °;C). Stammlösungen sind bei -20 °;C bis zu 2 Monate haltbar.
Other Notes
Wolvetang, E.J., et al. 1994. FEBS Lett.339, 40.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxizität: Reizstoff (B)
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Birte Plitzko et al.
Bio-protocol, 8(10), e2850-e2850 (2018-05-20)
Mammalian cells generate ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) metabolism. Cancer cells are known to reprogram their metabolism using different strategies to meet energetic and anabolic needs ( Koppenol et al., 2011 ; Zheng, 2012). Additionally, each cancer
Thomas A Ryan et al.
The EMBO journal, 39(11), e102539-e102539 (2020-04-21)
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Current protocols in cell biology, 86(1), e99-e99 (2019-12-27)
Mitophagy is a selective autophagy process that specifically removes damaged mitochondria via general autophagy. The two major recessive Parkinson's disease genes PINK1 and Parkin play essential roles in mitophagy initiation, increasing the interest in mitophagy in both basic and translational
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 495455-10MG | 04055977199734 |
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Could you provide information on the proportions or ratio of Oligomycin A, B, and C in this mixture? Additionally, are the proportions consistent between lots?
1 answer-
Helpful?
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As for the oligomycin(495455),what solvent can I use to dissolve it in order to preserve it as long as possible?
1 answer-
Oligomycin is soluble in DMSO at 50 mg/mL, in ethanol at 250 mg/mL, and in acetone at 50 mg/mL. The solution is stable for at least a week at 0-4 °C and for several months when stored frozen in aliquots at -20 °C.
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