482200

Nimodipine

An L-type Ca²⁺ channel blocker.

• Synonym(e): Nimodipine, 1,4-Dihydro-2,6-dimethyl-4-(3ʹ-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl Ester
• Empirische Formel (Hill-System): C₂₁H₂₆N₂O₇
• CAS-Nummer: 66085-59-4
• Molekulargewicht: 418.44
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00153848
• Assay: >98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Level: 100
• description: Merck USA index - 14, 6551
• assay: >98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: DMSO: 25 mg/mL, methanol: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [N+](=O)([O-])c1cc(ccc1)C2C(=C(NC(=C2C(=O)OCCOC)C)C)C(=O)OC(C)C
• InChI: 1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
• InChI key: UIAGMCDKSXEBJQ-UHFFFAOYSA-N

Beschreibung

General description

An L-type Ca²⁺ channel blocker. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Also reported to block TNF-α and LPS-induced iNOS activity (IC₅₀ = 36 pM) in mouse astroglial cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
L-type Ca2⁺ channel blocker

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 36 pM blocking TNF-α and LPS-induced iNOS activity in mouse astroglial cells

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhu, D., et al. 1999. Life. Sci.65, PL 221.
Marchetti, C. and Usai, C. 1996. Neurosci. Lett. 207, 77.
Kappelle, A.C., et al. 1994. Br. J. Pharmacol.111, 887.
Weiss, J.H., et al. 1994. J. Neurochem. 62, 372.
Kappelle, A.C., et al. 1993. Br. J. Pharmacol.108, 780.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable