N149

Nimodipin

≥98% (HPLC), L-type Ca2+ channel antagonist, powder

• Synonym(e): 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsäure-(2-methoxyethyl)-(1-methylethyl)-ester, Isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridindicarboxylat
• Empirische Formel (Hill-System): C₂₁H₂₆N₂O₇
• CAS-Nummer: 66085-59-4
• Molekulargewicht: 418.44
• NACRES: NA.77
• PubChem Substance ID: 24277858
• UNSPSC Code: 12352200
• EC Number: 266-127-0
• MDL number: MFCD00153848
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 200

Eigenschaften

• Produktname: Nimodipin,
• assay: ≥98% (HPLC)
• Quality Level: 200
• form: powder
• color: off-white to yellow
• solubility: methanol: 62.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble, H₂O: insoluble
• originator: Bayer
• SMILES string: COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
• InChI: 1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
• InChI key: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
• Gene Information: human ... ADORA3(140), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNG1(786), NR3C2(4306) ; rat ... Adora1(29290), Adora2a(25369)

Beschreibung

Application

Nimodipine has been used:

• as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
• as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
• in the pharmacological studies for the measurement of spine voltage escape

Biochem/physiol Actions

Nimodipine is a potent L-type Ca²⁺ channel antagonist.

Nimodipine enhances the survival of dopaminergic substantia nigra neurons.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Photosensitive

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves