454202

8-Methoxymethyl-3-isobutyl-1-methylxanthine

A cell-permeable selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

• Synonym(e): 8-Methoxymethyl-3-isobutyl-1-methylxanthine, 8-Methoxymethyl-IBMX
• Empirische Formel (Hill-System): C₁₂H₁₈N₄O₃
• CAS-Nummer: 78033-08-6
• Molekulargewicht: 266.30
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00211081
• Assay: ≥98% (TLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze

Eigenschaften

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: ethanol: 2 mg/mL, DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [nH]1c2c(nc1COC)N(C(=O)N(C2=O)C)CC(C)C
• InChI: 1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
• InChI key: NBLBCGUCPBXKOV-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I; IC₅₀ = 4 µM).

A cell-permeable, selective inhibitor of Ca²⁺-calmodulin-dependent phosphodiesterase (PDE I, IC₅₀ = 4 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE 1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 µM against Ca2+-calmodulin-dependent phosphodiesterase (PDE I)

Preparation Note

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jackson, E.K., et al. 1997. J. Cardiovasc. Pharmacol. 30, 798.
Ahn, H.S., et al. 1989. Biochem. Pharmacol.38, 3331.
Han, P., et al. 1989. J. Biol. Chem.274, 22337.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable