The peptide sequence is MCA-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH₂, where Dpa represents 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl and Nva denotes L-norvaline. Before cleavage, the fluorescence of MCA is quenched by Dpa. Hydrolysis of the Ala-Nva bond separates the highly fluorogenic MCA group from the Dpa quencher, resulting in an increase in MCA fluorescence.
444212
MMP-2 Substrate, Fluorogenic
A quenched fluorescence substrate for MMP-2 (gelatinase A; kcat/Km = 3.97 x 10⁵ M⁻¹s⁻¹).
Synonym(e):
MMP-2 Substrate, Fluorogenic
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 1 mg | Warenkorb auf Verfügbarkeit prüfen | € 283,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C49H68N14O15
Molekulargewicht:
1093.15
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated, protect from light
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
fluorescence
λex ~325 nm, λem ~393 nm
shipped in
ambient
storage temp.
−20°C
General description
A quenched fluorescence substrate for MMP-2 (gelatinase A; kcat/Km = 3.97 x 105 M-1s-1; excitation maximum: ~325 nm; emission maximum: ~393 nm).
Biochem/physiol Actions
Cell permeable: no
Primary Target
A quenched fluorescence substrate for MMP-2 (gelatinase A)
A quenched fluorescence substrate for MMP-2 (gelatinase A)
Product does not compete with ATP.
Reversible: no
Other Notes
MCA-Pro-Leu-Ala-Nva-Dpa-Ala-Arg-NH₂[Dpa = 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl; Nva = L-norvaline]
Murphy, G., et al. 1994. J. Biol. Chem. 269, 6632.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) |
| form lyophilized solid | form solid | form lyophilized solid | form lyophilized solid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 10 mg/mL | solubility DMSO: soluble | solubility DMSO: soluble, Tris-buffered saline, pH 7.6: soluble | solubility DMSO: 5 mg/mL |
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Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 444212-1MG | 04055977205619 |
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what is the sequence of this peptide and what is the fluorophore label
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