09-066

Anti-ASPM Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Abnormal spindle protein homolog, Asp homolog, asp (abnormal spindle) homolog, microcephaly associated (Drosophila), asp (abnormal spindle)-like, microcephaly associated, asp (abnormal spindle)-like, microcephaly associated (Drosophila), microcephaly, pr
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ELISA, IHC
• Citations: 4

Eigenschaften

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: rat, human
• species reactivity (predicted by homology): chimpanzee, primate
• technique(s): ELISA: suitable, immunohistochemistry: suitable
• NCBI accession no.: NP_060606
• UniProt accession no.: Q8IZT6
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... ASPM(259266)

Beschreibung

General description

218, 95, 75 kDa Observed UniProtKB/Swiss-Prot entry Q8IZT6 describes 2 isoforms produced by alternative splicing: Isoform 1 at 409.800kDa and Isoform 2 at 217.794kDa Multiple other isoforms in ref: Human Molecular Genetics, 2005, Vol. 14, No. 15 2155–2165.

The ASPM gene is the human ortholog of the Drosophila melanogaster ′abnormal spindle′ gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis.

Immunogen

KLH-conjugated linear peptide corresponding to human ASPM.

Application

Anti-ASPM Antibody detects level of ASPM & has been published & validated for use in IH, ELISA.

ELISA: Tested in direct ELISA against the ASPM immunogen.

Research Category
Signaling

Research Sub Category
Cell Cycle, DNA Replication & Repair

Biochem/physiol Actions

This antibody recognizes ASPM.

Physical form

Affinity purified

Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human ductal carcinoma tissue

Immunohistochemistry Analysis: 1:300 dilution of this antibody detected ASPM in human ductal carcinoma tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable