03-0191-00

SMC^® Human IFN-β1 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IFNβ1 in human serum and plasma

• Synonym(e): Interferon β-1 immunoassay kit, Interferon beta-1 Single Molecule Counting Kit, Interferon beta-1 immunoassay kit, Interferon beta-1 ultra-sensitive immunoassay
• NACRES: NA.84
• UNSPSC Code: 12161503
• Species reactivity: human
• Technique(s): single molecule counting: suitable
• Usage: kit sufficient for 96 wells
• Compatibility: for use with FemtoQuest^™ and SMCxPRO^® instruments

Eigenschaften

• Produktname: SMC^® Human IFN-β1 High Sensitivity Immunoassay Kit,
• description: 0.07-0.30 pg/mL, refer to CoA for lot-specific LLOQ, Used for ultrasensitive quantification of Human IFNβ1 in human serum and plasma
• product line: SMC^®
• usage: kit sufficient for 96 wells
• species reactivity: human
• technique(s): single molecule counting: suitable
• input: plasma (K2 EDTA); serum
• UniProt accession no.: P01574
• compatibility: for use with FemtoQuest^™ and SMCxPRO^® instruments
• relevant disease(s): infectious diseases; autoimmune diseases; neurodegenerative disorders
• shipped in: wet ice
• storage temp.: 2-8°C

Beschreibung

General description

A member of the type I interferon family of glycoprotein second messengers, human Interferon Beta (IFN-ß1) has been associated with antiviral activity as a secreted factor from infected cells that mediates innate immunity in neighboring cells. In addition, IFN-β1 has also been utilized as treatment for Multiple Sclerosis (MS) due to its ability to ameliorate inflammation in the central nervous system in this disease.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease / Neurodegenerative Diseases / Neurodegenerative Medicine / Virology / Infectious Diseases - Viral / Immunological Signaling

Features and Benefits

• Reveal the First Responders of Immunity: IFN-β1 is a frontline cytokine in antiviral defense; this kit helps you detect its earliest signals.
• Empower Neuro and Autoimmune Research: Quantify IFN-β1 in studies of multiple sclerosis, lupus, and other inflammatory conditions with confidence.
• Precision You Can Count On: Built for reproducibility, with tight CVs across operators and days, because your data deserves consistency.
• Molecular-Level Listening: Detects IFN-β1 at whisper-quiet levels, down to 150 fg/mL, thanks to ultrasensitive SMC^® technology.

Packaging

96 well assay

Analysis Note

• Sensitivity: LLOQ 150 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 70-170,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 108% Plasma: 108%
• Recovery: Serum 88% Plasma: 93%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

• Assay Buffer
• IFN-β1 Coated Beads
• Standard Diluent
• IFN-β1 Detection Antibody
• IFN-β1 Standard
• 10X Wash Buffer
• Buffer D
• Elution Buffer B

Although IFNβ1 was detectable in non-human primate, rat, mouse, feline, and canine samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• hcodes: H302 + H332,H311,H319,H360FD,H412,EUH430
• pcodes: P201 - P202 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B