U111

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate

≥98% (HPLC), κ opioid receptor agonist, solid

• Synonym(e): trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₉H₂₆Cl₂N₂O · HCl · xH₂O
• CAS-Nummer: 114528-79-9
• Molekulargewicht: 405.79 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278019
• NACRES: NA.77
• MDL number: MFCD11044455
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Produktname: (−)-trans-(1S,2S)-U-50488 hydrochloride hydrate, solid, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]22/D -39.0 to -32.0°, c = 0.5 in methanol(lit.)
• storage condition: desiccated
• color: white
• solubility: H₂O: 13 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cl.CN([C@H]1CCCC[C@@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

Beschreibung

Application

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta)[1].

Biochem/physiol Actions

Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.

Preparation Note

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)