T8024

Tetrodotoxin

≥98% (HPLC), powder

• Synonym(e): Fugu poison, TTX
• Empirische Formel (Hill-System): C₁₁H₁₇N₃O₈
• CAS-Nummer: 4368-28-9
• Molekulargewicht: 319.27
• EC Number: 224-458-8
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900493
• Beilstein/REAXYS Number: 49176
• MDL number: MFCD00213719

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.), strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• storage temp.: 2-8°C
• SMILES string: [H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO
• InChI: 1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
• InChI key: CFMYXEVWODSLAX-IXUBDLNJSA-N
• Gene Information: rat ... Scnn1g(24768)

Beschreibung

Application

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N)[1]. Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca²⁺ currents in rat hippocampal interneurons[2].

Biochem/physiol Actions

Reversible, selective blocker of Na⁺ channels.

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Preparation Note

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Lagerklasse: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges